Familial autoimmune myasthenia gravis.

Bergoffen, J; Zmijewski, C M; Fischbeck, K H · Neurology · 1994

case_report · Level V

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Abstract

We describe a family with parental consanguinity and five of 10 siblings affected by late-onset autoimmune myasthenia gravis. We propose a genetic mechanism as a predisposing factor in this family. Our analysis excludes the major histocompatibility complex, the beta subunit of the acetylcholine receptor, and the T-cell receptor alpha and beta subunits as candidate genes for the disorder in this family.

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