Insulin independence in a type 1 diabetic patient after encapsulated islet transplantation.

Soon-Shiong, P; Heintz, R E; Merideth, N; Yao, Q X; Yao, Z; Zheng, T; Murphy, M; Moloney, M K et al. · Lancet · 1994

case_report · Level V

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Abstract

Identification of a biocompatible immunoprotective membrane to prevent graft rejection remained elusive until the development of microcapsules formulated in alginate high in guluronic acid. We report insulin independence in a type 1 diabetic patient after encapsulated islet transplantation. Encapsulated human islets were injected intraperitoneally in a diabetic patient with a functioning kidney graft. Insulin independence with tight glycaemic control was demonstrated 9 months after the procedure. These results warrant a trial of a high dose of encapsulated islets in early-onset diabetic patients.

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