Linkage of the VNTR/insulin-gene and type I diabetes mellitus: increased gene sharing in affected sibling pairs.
case_control · Level III
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- Record sourced from PubMed, PMID 7909987.
- Also identified by PMC identifier 1918272.
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Abstract
Ninety-six multiplex type I diabetic families were typed at the 5' flanking region of the insulin gene by using a PCR assay that better resolves the VNTR into multiple alleles. Affected sibling pairs shared 2, 1, and 0 VNTR alleles--identical by descent--at a frequency of .47, .45, and .08, respectively, a ratio that deviated from the expected 1:2:1 ratio (P < .001). These results confirm linkage of the chromosome 11p15.5 region with type I diabetes mellitus susceptibility.
Medical subject headings
- Chromosomes, Human, Pair 11
- Diabetes Mellitus, Type 1
- Genetic Linkage
- HLA-DR Antigens
- Insulin
- Repetitive Sequences, Nucleic Acid