HTLV-I proviral DNA in umbilical cord blood of babies born to carrier mothers.
case_series · Level IV
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- Record sourced from PubMed, PMID 7910326.
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Abstract
Human T-lymphotropic virus type I (HTLV-I) in cord blood raises the possibility of intrauterine transmission as an alternative pathway to transmission via breast milk. However, none of 7 children with HTLV-I proviral DNA positive cord blood had seroconverted by 24-48 months. Contamination of cord blood by maternal blood was precluded on the basis of viral load and IgA concentration. Thus cord blood proviral DNA is not a hallmark of intrauterine infection. Moreover, none of the cord blood samples of 9 formula-fed children later confirmed to be infected was positive for HTLV-I, indicating that intrauterine infection is not a likely candidate as an alternative pathway.
Medical subject headings
- DNA, Viral
- Fetal Blood
- HTLV-I Infections
- Human T-lymphotropic virus 1
- Proviruses