HIV-1/HIV-2 seronegativity in HIV-1 subtype O infected patients.
case_series · Level IV
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- Record sourced from PubMed, PMID 7910884.
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Abstract
Nine patients with atypical HIV-1 western blot profiles were diagnosed as having HIV-1 subtype O infection. All the patients were living in France; eight originated from Cameroon and one from France. Lymphocyte DNA amplification by the polymerase chain reaction was only positive when HIV-1 subtype O specific primers were used. Preliminary sequence analysis of amplified products and serological reactivity against a specific subtype O synthetic env peptide confirmed HIV-1 subtype O infection. HIV-1/HIV-2 enzyme-linked immunosorbent assays, especially those based on env peptides or on the sandwich format, can be negative in HIV-1 subtype O infection.
Medical subject headings
- Acquired Immunodeficiency Syndrome
- HIV Seronegativity
- HIV-1
- HIV-2