Molecular and functional analysis of a lymphocyte chemoattractant factor: association of biologic function with CD4 expression.
basic_science · Level V
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- Record sourced from PubMed, PMID 7910967.
- Also identified by PMC identifier 43941.
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Abstract
Lymphocyte chemoattractant factor (LCF) is a lymphocyte cell product that stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. In concert with its chemoattractant activity, LCF induces human T-lymphocyte expression of interleukin 2 receptor. Here we describe the molecular cloning of cDNA encoding human LCF. It is a novel interleukin with no significant homology to any previously described cytokine families. There is an absolute requirement for both autoaggregation of LCF monomers and for membrane-expressed CD4 molecules for LCF-induced migration in lymphocytes.
Medical subject headings
- CD4 Antigens
- CD4-Positive T-Lymphocytes
- Chemotactic Factors
- Lymphokines