Mediation of renal cyst formation by hepatocyte growth factor.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 7916076.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Hepatocyte growth factor (HGF) is a potent mitogen for renal tubular cells, and HGF and its receptor (c-met proto-oncogene product, Met) can induce lumen formation in epithelial cells. We measured the concentration of HGF in cyst fluids from patients with renal cystic diseases. The concentration of HGF was high in proximal cyst fluid (mean 2.45 vs 0.42 ng/mL in distal cysts). Cyclic AMP concentration was higher in distal than in proximal cysts (663 vs 6.0 pmol/L). mRNA of HGF and Met were co-expressed in cyst walls from cases with polycystic kidney disease. These findings suggest that HGF is a growth factor that may mediate human renal cyst genesis.
Medical subject headings
- Hepatocyte Growth Factor
- Polycystic Kidney, Autosomal Dominant
- Proto-Oncogene Proteins
- Receptor Protein-Tyrosine Kinases