The fission yeast cdc18+ gene product couples S phase to START and mitosis.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 7916658.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Commitment to the cell cycle in fission yeast requires the function of the cdc10+ transcriptional activator at START. The product of the cdc18+ gene is a major downstream target of cdc10+, and transcription of cdc18+ is activated by cdc10+ during passage through START. The cdc18+ function is required for entry into S phase. In addition, the product of the cdc18+ gene is part of the checkpoint control that prevents mitosis from occurring until S phase is completed. Thus, cdc18+ plays a key role in coupling S phase to START and mitosis.
Medical subject headings
- Cell Cycle
- Cell Cycle Proteins
- Fungal Proteins
- Genes, Fungal
- Schizosaccharomyces