Heat-shock protein 65 and activated gamma/delta T cells in injured arteries.
basic_science · Level V
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- Record sourced from PubMed, PMID 7934348.
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Abstract
Because immune mechanisms are implicated in atherogenesis, we investigated the T-lymphocyte subset and factors related to its activation after acute arterial ligation (22 ligated and 13 non-ligated specimens). Ligated arteries produced heat-shock protein 65 (hsp65) and were infiltrated with activated T cells (mostly dendritic, CD3+, CD4-, CD8-, and gamma/delta T-cell-receptor bearing). The protein was found with dendritic T cells, with immunogold-labelled hsp65 beside the dendritic processes. Thus, the immune reaction after acute arterial injury may be associated with binding and recognition of in-situ hsp65 by dendritic gamma/delta T-cells.
Medical subject headings
- Arteries
- Heat-Shock Proteins
- Receptors, Antigen, T-Cell, gamma-delta
- T-Lymphocytes
- Wounds and Injuries