The effects of 4-aminopyridine on cognitive function in patients with multiple sclerosis: a pilot study.
rct · Level II
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Abstract
4-Aminopyridine (4-AP) has a favorable effect on the disability of certain patients with MS. We investigated the effect of 4-AP on neuropsychological performance in 20 MS patients using a randomized, double-blind, placebo-controlled, crossover design. Although there was a trend for improved performance with 4-AP for two of the tests, we could not demonstrate significant effects of 4-AP on cognitive function.
Medical subject headings
- 4-Aminopyridine
- Cognition Disorders
- Multiple Sclerosis