Paraneoplastic opsoclonus-myoclonus associated with anti-Hu antibody.
case_report · Level V
Where this comes from
- Record sourced from PubMed, PMID 7936310.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
We report a 74-year-old woman with opsoclonus, myoclonus, ataxia, and encephalopathy who had small-cell lung cancer and high titers of anti-Hu antibody in her serum. At autopsy, there were perivascular inflammatory infiltrates in the brainstem, putamen, and meninges overlying the orbital frontal cortex. Immunohistochemical studies showed the expression of the Hu antigens by the tumor and the presence of deposits of anti-Hu IgG in the patient's cortex, brainstem, and cerebellum, suggesting that anti-Hu immune response was related to the patient's clinical syndrome. This case of paraneoplastic opsoclonus, myoclonus, ataxia, and encephalopathy expands the spectrum of neurologic dysfunction associated with the anti-Hu antibody.
Medical subject headings
- Antibodies
- Myoclonus
- Nerve Tissue Proteins
- Ocular Motility Disorders
- Paraneoplastic Syndromes
- RNA-Binding Proteins