Interaction of the protein kinase Raf-1 with 14-3-3 proteins.
basic_science · Level V
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Abstract
Members of a family of highly conserved proteins, termed 14-3-3 proteins, were found by several experimental approaches to associate with Raf-1, a central component of a key signal transduction pathway. Optimal complex formation required the amino-terminal regulatory domain of Raf-1. The association of 14-3-3 proteins and Raf-1 was not substantially affected by the activation state of Raf.
Medical subject headings
- Protein Serine-Threonine Kinases
- Proteins
- Proto-Oncogene Proteins
- Signal Transduction
- Tyrosine 3-Monooxygenase