The power of interval mapping of quantitative trait loci, using selected sib pairs.
other · Level V
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- Record sourced from PubMed, PMID 7942859.
- Also identified by PMC identifier 1918307.
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Abstract
The interval-mapping procedure of Fulker and Cardon for analysis of a quantitative-trait loci (QTL) is extended for application to selected samples of sib pairs. Phenotypic selection of sib pairs, which is known to yield striking increases in power when a single marker is used, provides further increases in power when the interval-mapping approach is used. The greatest benefits of the combined approach are apparent with coarse maps, where QTLs of relatively modest (15%-20%) heritability can be detected with widely spaced markers (40-60 cM apart) in reasonably sized sibling samples. Useful information concerning QTL location is afforded by interval mapping in both selected and unselected samples.
Medical subject headings
- Genetics, Medical
- Models, Genetic