Long-term follow up in type A insulin resistant syndrome treated by insulin-like growth factor I.
case_report · Level V
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- Record sourced from PubMed, PMID 7944536.
- Also identified by PMC identifier 1029947.
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Abstract
Insulin-like growth factor I (IGF-I) is a useful therapeutic agent in insulin resistant diabetes mellitus due to insulin receptor disease because of its hypoglycaemic effects through the IGF-I receptor. A girl with typical type A insulin resistant syndrome was treated with IGF-I for two years and the treatment was effective in ameliorating hyperglycaemia. Overproduction of testosterone in polycystic ovaries was aggravated with this treatment, however. Therefore, IGF-I treatment may be used for glycaemic control but with caution because of its possible side effect of aggravating hyperandrogenism in these patients.
Medical subject headings
- Acanthosis Nigricans
- Diabetes Mellitus
- Insulin Resistance
- Insulin-Like Growth Factor I
- Polycystic Ovary Syndrome
- Testosterone