Increased urinary nitrate excretion in rats with adjuvant arthritis.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 7944643.
- Also identified by PMC identifier 1005398.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
In rats with adjuvant arthritis measurements were taken of the urinary excretion of nitrate, reflecting endogenous nitric oxide (NO) formation, and cyclic guanosine monophosphate (cGMP). Urinary nitrate was determined by gas chromatography, cGMP by radioimmunoassay. A significant (p < 0.001), more than three fold increase of urinary nitrate excretion was found in rats 20 days after induction of adjuvant arthritis compared with non-arthritic rats. There was no significant difference in urinary cGMP excretion between arthritic rats and control animals. The data suggest that the dramatic increase of urinary nitrate excretion is due to increase of NO synthesis by the inducible form of NO synthase.
Medical subject headings
- Arthritis, Experimental
- Nitrates