Effect of four i.v. induction agents on T-lymphocyte proliferations to PHA in vitro.
basic_science · Level V
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Abstract
Anaesthetic agents are believed to have an adverse effect on human immunity. We have studied the effects of four i.v. induction agents, thiopentone, methohexitone, etomidate and propofol, on T-lymphocyte proliferations to phytohaemagglutinin in vitro. We found that at plasma concentrations similar to those obtained after induction doses, all drugs, with the exception of propofol, caused depression of T-lymphocyte function.
Medical subject headings
- Anesthetics, Intravenous
- Immune Tolerance
- T-Lymphocytes