Gene therapy utilizing drug resistance genes: a review.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 7951004.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
The generation of drug resistant bone marrow may facilitate the development of aggressive chemotherapeutic regimens that might otherwise be lethal due to marrow toxicity. With the availability of technology that permits in vitro manipulation of human marrow and peripheral blood stem cells, it is now possible to introduce genes that confer drug resistance to these hematopoietic progenitors. Animal models and in vitro work with human progenitors using drug resistance genes are reviewed.
Medical subject headings
- Antineoplastic Agents
- Drug Resistance
- Genetic Therapy
- Hematopoietic Stem Cell Transplantation
- Hematopoietic Stem Cells