Acute arterial thrombosis in a patient with breast cancer after chemotherapy with 5-fluorouracil, doxorubicin, leucovorin, cyclophosphamide, and interleukin-3.

Theodossiou, C; Kroog, G; Ettinghausen, S; Tolcher, A; Cowan, K; O'Shaughnessy, J · Cancer · 1994

case_report · Level V

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Abstract

Interleukin-3 (IL-3) is an experimental agent used to ameliorate neutropenia in patients receiving chemotherapy. Arterial thrombotic episodes after use of IL-3 have not been reported previously. The case of a patient with Stage III adenocarcinoma of the breast who developed hypotension and acute cerebellar artery and superior mesenteric artery thrombosis after receiving chemotherapy and treatment with IL-3 is reported. To the authors' knowledge, this is the first patient with arterial thrombosis reported after treatment with IL-3. Interleukin-3 may be associated with increased propensity for thrombosis.

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