Somatomedin C (insulin-like growth factor 1) levels decrease during acute changes of stress related hormones. Relevance for fibromyalgia.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 7966079.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
To determine the effects of stress hormones on insulin-like growth factor 1 (IGF-1). Insulin induced hypoglycemia (< 3 mmol/l) and clonidine induced depression of noradrenergic tone were used to assess the acute effects of cortisol, human growth hormone (hGH), and norepinephrine (NE). Despite the increase of hGH during hypoglycemia, a statistically significant decrease of IGF-1 was observed along with the expected rise of cortisol and NE. To eliminate the role played by NE, NE tone was depressed by administering clonidine. A statistically significant decrease of IGF-1 was also observed. Acute cortisol release or a NE decrease induce low IGF-1 levels.
Medical subject headings
- Fibromyalgia
- Growth Hormone
- Hydrocortisone
- Insulin-Like Growth Factor I
- Norepinephrine