Crystal structure at 2.2 A resolution of the MHC-related neonatal Fc receptor.
basic_science · Level V
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Abstract
The three-dimensional structure of the rat neonatal Fc receptor (FcRn) is similar to the structure of molecules of the major histocompatibility complex (MHC). The counterpart of the MHC peptide-binding site is closed in FcRn, making the FcRn groove incapable of binding peptides. A dimer of FcRn heterodimers seen in the crystals may represent a receptor dimer that forms when the Fc portion of a single immunoglobulin binds. An alternative use of the MHC fold for immune recognition is indicated by the FcRn and FcRn/Fc co-crystal structures.
Medical subject headings
- Animals, Newborn
- Histocompatibility Antigens Class I
- Receptors, Fc