Normal CAG repeat length in the Huntington's disease gene in senile chorea.
case_series · Level IV
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- Record sourced from PubMed, PMID 7969980.
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Abstract
There is a widely held belief that most patients presenting with senile chorea have late-onset Huntington's disease (HD) with an unknown family history. We measured CAG trinucleotide repeat expansion in the HD gene in four patients with a clinical presentation of senile chorea and found that CAG repetition lengths were normal. These findings support senile chorea as being a distinct clinical entity that is nosologically separate from late-onset HD.
Medical subject headings
- DNA
- Huntington Disease
- Repetitive Sequences, Nucleic Acid