Pharmacokinetics and pharmacodynamics of tizanidine.

Roberts, R C; Part, N J; Pokorny, R; Muir, C; Leslie, G C; Emre, M · Neurology · 1994

review · Level V

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Abstract

The relationship among tizanidine dose, plasma concentration, and antispastic action is linear in nature. Response to a given dose of this agent varies among patients, and determining the appropriate clinical dose requires individual titration.

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