DNA loop repair by human cell extracts.
basic_science · Level V
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- Record sourced from PubMed, PMID 7973637.
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Abstract
An activity in human cell extracts is described that repairs DNA with loops of five or more unpaired bases. Repair is strand-specific and is directed by a nick located 5' or 3' to the loop. This repair is observed in a colorectal cancer cell line that is devoid of a wild-type hMLH1 gene and is deficient in repair of mismatches. However, a cell line with deletions in both hMSH2 alleles is deficient in repair of both loops and mismatches. Defects in loop repair may be relevant to the repetitive-sequence instability observed in cancers and other hereditary diseases.
Medical subject headings
- Colorectal Neoplasms
- DNA Repair
- DNA-Binding Proteins
- Neoplasm Proteins
- Nucleic Acid Heteroduplexes
- Proto-Oncogene Proteins