The function of KGF in morphogenesis of epithelium and reepithelialization of wounds.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 7973639.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
The function of keratinocyte growth factor (KGF) in normal and wounded skin was assessed by expression of a dominant-negative KGF receptor transgene in basal keratinocytes. The skin of transgenic mice was characterized by epidermal atrophy, abnormalities in the hair follicles, and dermal hyperthickening. Upon skin injury, inhibition of KGF receptor signaling reduced the proliferation rate of epidermal keratinocytes at the wound edge, resulting in substantially delayed reepithelialization of the wound.
Medical subject headings
- Fibroblast Growth Factors
- Growth Substances
- Keratinocytes
- Receptors, Fibroblast Growth Factor
- Receptors, Growth Factor
- Skin
- Wound Healing