Prevention of T cell anergy by signaling through the gamma c chain of the IL-2 receptor.
basic_science · Level V
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Abstract
When stimulated through their antigen receptor without requisite costimulation, T cells enter a state of antigen-specific unresponsiveness termed anergy. In this study, signaling through the common gamma chain of the interleukin-2 (IL-2), IL-4, and IL-7 receptors in the presence of antigen was found to be sufficient to prevent the induction of anergy. After culture with IL-2, IL-4, or IL-7, Jak3 kinase was tyrosine-phosphorylated, which correlated with the prevention of anergy. Therefore, a signal through the common gamma chain may regulate the decision of T cells to either clonally expand or enter a state of anergy.
Medical subject headings
- Clonal Anergy
- Receptors, Interleukin-2
- Signal Transduction
- T-Lymphocytes