Long-term synapse loss induced by focal blockade of postsynaptic receptors.
basic_science · Level V
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Abstract
Focal application in vivo of alpha-bungarotoxin to block neurotransmission in a small region of a neuromuscular junction causes long-lasting synapse elimination at that site. In contrast, blockade of neurotransmission throughout a junction does not cause synapse elimination. These and related experiments indicate that active synaptic sites can destabilize inactive synapses in their vicinity.
Medical subject headings
- Receptors, Cholinergic
- Synapses