Acute ataxic neuropathy with cross-reactive antibodies to GD1b and GD3 gangliosides.
case_report · Level V
Where this comes from
- Record sourced from PubMed, PMID 7991134.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
We report a patient with an acute, self-limiting neuropathy consisting of ataxia and areflexia, but without ophthalmoplegia or limb weakness, with transient, high-titer serum IgG antibodies to a single NeuAc(alpha 2-8)NeuAc-linked disialosyl epitope, as found on GD1b and GD3 gangliosides. The serum did not react with GQ1b, GT1a, or GT1b. This atypical case, which most closely represents an incomplete Miller Fisher syndrome, indicates that anti-GD1b/GD3 antibodies may be able to induce sensory ataxia.
Medical subject headings
- Ataxia
- Autoantibodies
- Gangliosides
- Reflex, Abnormal