Suppression of murine melanoma growth with a combination of microwave hyperthermia and local injection of interleukin 2.
basic_science · Level V
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Abstract
Local microwave hyperthermia in combination with local injections of interleukin 2 (IL-2) was found to exert a remarkable suppressive effect on murine melanoma growth. Both of these therapeutic modalities caused marked tumour infiltration with natural killer cells. After microwave hyperthermia or IL-2 injection alone there was minimal T-cell infiltration, but T cells were more in evidence following combination therapy.
Medical subject headings
- Hot Temperature
- Interleukin-2
- Melanoma, Experimental
- Microwaves
- Skin Neoplasms