Papuloerythroderma of Ofuji: a report of three cases and review of the literature.

Abstract

Papuloerythroderma of Ofuji is a rare, distinctive entity featuring widespread erythematous, flat-topped papules, with a striking sparing of body folds (the so-called 'deck-chair' sign), and peripheral eosinophilia. We report three elderly men who showed the typical features of this disease, and who responded to corticosteroid therapy. Immunohistochemical studies with anti-S-100 and UCHL-1 (CD45 RO) antibodies indicated the presence of abundant dendritic cells and mature T cells in the dermis. In addition, one patient had concomitant tinea corporis. Treatment with griseofulvin alone resulted in clearing of the fungal infection and improvement of his papuloerythroderma, and, worsening of his papuloerythroderma occurred when the tinea relapsed.