Primary structure and characterization of a small-conductance inwardly rectifying potassium channel from human hippocampus.
basic_science · Level V
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- Record sourced from PubMed, PMID 8016146.
- Also identified by PMC identifier 44174.
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Abstract
We have isolated a human hippocampus cDNA that encodes an inwardly rectifying potassium channel, termed HIR (hippocampal inward rectifier), with strong rectification characteristics. Single-channel recordings indicate that the HIR channel has an unusually small conductance (13 pS), distinguishing HIR from other cloned inward rectifiers. RNA blot analyses show that HIR transcripts are present in heart, skeletal muscle, and several different brain regions, including the hippocampus.
Medical subject headings
- Hippocampus
- Potassium Channels