AIDS-associated cryptosporidiosis with gastric stricture and a therapeutic response to paromomycin.

Abstract

AIDS-associated cryptosporidiosis has been associated with severe, watery diarrhea and with multifocal biliary stricture. Gastric involvement has not been reported prominently. We report here the case of a 28-yr-old AIDS patient who developed typical watery diarrhea, followed by subtotal gastric obstruction secondary to antral stricturing. Biopsy of the stricture revealed severe inflammation and marked cryptosporidial infestation. Extensive workup excluded causes of stricture. He was empirically treated with paromomycin, with a surprisingly positive therapeutic response and clinical resolution of obstruction. Antral stricture may be another manifestation of cryptosporidial infection in AIDS. Paromomycin deserves further evaluation as an agent for treatment of this infection.