An investigation of the local anaesthetic effects of pethidine in volunteers.
rct · Level II
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Abstract
We have investigated the local anaesthetic effects of 0.1% and 0.2% pethidine compared with 0.5% prilocaine using an intravenous regional anaesthetic technique, in a randomised, double-blind study in volunteers. Both pethidine and prilocaine produced a sensory and motor blockade, although the latter had a more profound effect, with a faster onset and slower recovery. Pethidine in low concentration clearly has a local anaesthetic action on peripheral nerves.
Medical subject headings
- Anesthesia, Local
- Anesthetics, Local
- Meperidine
- Prilocaine