Plasma beta-endorphin concentrations and analgesia-muscle relaxation in the newborn infant supported by mechanical ventilation.

Ionides, S P; Weiss, M G; Angelopoulos, M; Myers, T F; Handa, R J · J Pediatr · 1994

rct · Level II

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Abstract

We evaluated the effects of pancuronium and opiates on plasma beta-endorphin concentrations in 25 infants supported by mechanical ventilation. Infants receiving opiate were randomly assigned to receive either fentanyl or morphine. There was no change in beta-endorphin concentrations after administration of pancuronium, whereas both fentanyl and morphine reduced beta-endorphin concentrations by approximately 60%.

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