Cytogenetic characterization of tenosynovial giant cell tumors (nodular tenosynovitis).
case_series · Level IV
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Abstract
Chromosome investigation in six localized forms of tenosynovial giant cell tumors, also known as modular tenosynovitis, revealed an identical translocation between chromosomes 1 and 2, t(1;2)(p11;q35-36) in three tumors, a variant translocation t(1;5)(p11;q22) in a fourth case, and a t(2;16)(q33;q24) in a fifth case. One case showed a normal karyotype. Although morphologically rather uniform, these benign tumors appear to be cytogenetically heterogeneous, but the chromosome changes seem to cluster in 2 regions, 1p11 and 16q24.
Medical subject headings
- Chromosomes, Human, Pair 1
- Chromosomes, Human, Pair 2
- Chromosomes, Human, Pair 5
- Giant Cell Tumors
- Synovial Membrane
- Translocation, Genetic