Deficiency of both protein C and protein S in a family with ischemic strokes in young adults.

Köller, H; Stoll, G; Sitzer, M; Burk, M; Schöttler, B; Freund, H J · Neurology · 1994

case_report · Level V

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Abstract

Protein C and protein S deficiencies increase the risk of venous thrombosis and pulmonary embolism, but their role in arterial thrombosis or embolism is controversial. We describe cerebral ischemia in two young women in a family with inherited deficiencies of both proteins C and S and provide evidence that a combined deficiency of proteins C and S may be a high risk factor for ischemic stroke in young adults.

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