Hypersensitivity to molybdenum as a possible trigger of ANA-negative systemic lupus erythematosus.
case_report · Level V
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- Record sourced from PubMed, PMID 8037499.
- Also identified by PMC identifier 1005357.
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Abstract
After implantation of two metal plates a 24 year old woman developed fever of unknown origin and successively more symptoms of an ANA-negative systemic lupus erythematosus (SLE). These symptoms resolved after removal of the plates and recurred during patch testing of the metal components, which showed a reaction to molybdenum. A lymphocyte transformation test indicated a delayed-type hypersensitivity to molybdenum. Subsequent progressive flare ups of SLE appeared without molybdenum reexposure. This is the first report suggesting the existence of a hypersensitivity to molybdenum, which may act as another environmental trigger for SLE.
Medical subject headings
- Drug Hypersensitivity
- Hypersensitivity, Delayed
- Lupus Erythematosus, Systemic
- Molybdenum