Epstein-Barr virus-associated large granular lymphocyte leukemia with cutaneous infiltration.
case_report · Level V
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Abstract
A 36-year-old man had a high titer of antibody to Epstein-Barr virus (EBV) and recurrent necrotizing papules and nodules on his face and oral mucosa. The disease was diagnosed as CD3+4- 8+ large granular lymphocyte leukemia of T-cell origin. Southern blot analysis demonstrated that EBV DNA was present in CD8+ lymphocytes; EBV antigens were also observed in these lymphocytes. These findings demonstrated that EBV latently infected the leukemic cells and may have played a role in the pathogenesis of this disease. This is the first report of an association between EBV and large granular lymphocyte leukemia of T-cell origin.
Medical subject headings
- Herpesviridae Infections
- Herpesvirus 4, Human
- Leukemia, T-Cell
- Leukemic Infiltration
- Skin
- Tumor Virus Infections