Design and synthesis of deoxynucleic guanidine: a polycation analogue of DNA.
basic_science · Level V
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- Record sourced from PubMed, PMID 8058725.
- Also identified by PMC identifier 44504.
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Abstract
The basic strategy is described for the connection of nucleosides by guanidinium (g) linkers to provide the positively charged deoxynucleic guanidine putative antigene agents. The synthetic procedures are provided for d(gT)n. Molecular modeling of double-stranded [d(gT)10.d(Ap)10] and the triple-helical hybrids [d(Tp)10.d(Ap)10.d(gT)10] and [d(gT)10.d(Ap)10.d(gT)10] suggest modes of interaction and anticipated structural features.
Medical subject headings
- DNA
- Guanidines
- Nucleic Acid Conformation