Failure of cefotaxime in the treatment of meningitis due to relatively resistant Streptococcus pneumoniae.
case_report · Level V
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Abstract
To our knowledge, we report the first failure of cefotaxime in the treatment of meningitis due to relatively resistant Streptococcus pneumoniae (MICs of penicillin and cefotaxime, 1 microgram/mL). Cure was achieved with a 14-day course of intravenous and intrathecal vancomycin. We recommend that in cases of meningitis caused by strains of S. pneumoniae for which MICs are > or = 1 microgram/mL, cefotaxime should be used with caution; however, if therapeutic failure is suspected therapy should be changed to intravenous and intrathecal vancomycin.
Medical subject headings
- Cefotaxime
- Meningitis, Bacterial
- Streptococcal Infections
- Streptococcus pneumoniae