Increasing complexity of the dystrophin-associated protein complex.
review · Level V
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- Record sourced from PubMed, PMID 8078878.
- Also identified by PMC identifier 44595.
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Abstract
Duchenne muscular dystrophy is a severe X chromosome-linked, muscle-wasting disease caused by lack of the protein dystrophin. The exact function of dystrophin remains to be determined. However, analysis of its interaction with a large oligomeric protein complex at the sarcolemma and the identification of a structurally related protein, utrophin, is leading to the characterization of candidate genes for other neuromuscular disorders.
Medical subject headings
- Cytoskeletal Proteins
- Dystrophin
- Membrane Glycoproteins
- Membrane Proteins
- Muscle Proteins
- Muscles