Multipoint mapping calculations for sperm-typing data.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 8079987.
- Also identified by PMC identifier 1918392.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
This paper explains how multipoint likelihoods can be computed for sperm-typing data. Experimental errors such as multiple sperm per tube, inadequate amplification, and contamination by exogenous DNA are explicitly taken into account. By limiting the number of sperm theoretically possible per tube to a predetermined maximum and by assuming no chiasma interference, maximum-likelihood estimation can be carried out rapidly using the theory of hidden Markov chains.
Medical subject headings
- Chromosome Mapping
- DNA Fingerprinting
- Models, Genetic
- Sex Chromosomes
- Spermatozoa