Fluoxetine abuse.

Tinsley, J A; Olsen, M W; Laroche, R R; Palmen, M A · Mayo Clin Proc · 1994

case_report · Level V

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Abstract

OBJECTIVE: In this report, we describe the abuse of fluoxetine (an antidepressant) in two patients who had histories of substance abuse. MATERIAL AND METHODS: Specific details of the stimulant effects of fluoxetine, used in excessive dosages and in conjunction with other drugs, are discussed. RESULTS: After hospitalization, our two patients were able to discontinue use of fluoxetine and had improved mentation. CONCLUSION: Although the mechanism for this phenomenon is unknown, we postulate that drug craving and behavioral factors are involved.

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