Linkage analysis of 19 French breast cancer families, with five chromosome 17q markers.

Mazoyer, S; Lalle, P; Narod, S A; Bignon, Y J; Courjal, F; Jamot, B; Dutrillaux, B; Stoppa-Lyonnett, D et al. · Am J Hum Genet · 1993

other · Level V

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Abstract

Nineteen French breast and breast-ovarian cancer families were tested for linkage with five chromosome 17q markers. The five breast-ovarian cancer families as a group give positive evidence for linkage, whereas the 14 breast cancer-only families do not. Heterogeneity of linkage of breast and breast-ovarian cancers is significant in France and supports the existence of more than one susceptibility gene.

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