Mapping of the X linked form of hyper IgM syndrome (HIGM1).
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- Record sourced from PubMed, PMID 8097258.
- Also identified by PMC identifier 1016299.
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Abstract
X linked immunodeficiency with hyperimmunoglobulinaemia M (HIGM1), which is characterised by agammaglobulinaemia together with excess IgM production reflecting an impairment of the immunoglobulin heavy chain class switch of B lymphocytes, has been mapped to Xq26. We report multipoint linkage data in six families with HIGM1 which show that the most likely position for the gene is close to HPRT with a maximum lod score of 4.89. The finding of recombinations between HIGM1 and both HPRT and DXS42 implies that HIGM1 is not allelic to X linked lymphoproliferative disease. These data will be useful in genetic counselling in families and will also be useful in testing candidate genes.
Medical subject headings
- Chromosome Mapping
- Genetic Linkage
- Hypergammaglobulinemia
- Immunoglobulin M
- X Chromosome