Disomic locus content mapping.
basic_science · Level V
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- Record sourced from PubMed, PMID 8108424.
- Also identified by PMC identifier 43170.
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Abstract
A linear genetic map may be constructed from segregation of markers in DNA fragments broken by radiation or shearing and/or incorporated into a vector: this is locus content mapping. Theory for monosomic locus content mapping is extended to disomy, making the phase of heterozygous markers informative for linkage and each clone potentially informative for every chromosome. Because there is no interference among breaks and phase may be reliable inferred for all heterozygous loci, multiple pairwise mapping is especially appropriate.
Medical subject headings
- Chromosome Mapping
- Models, Genetic