Visualization of damaged brain tissue after ischemic stroke with cobalt-55 positron emission tomography.
case_report · Level V
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Abstract
In animal experiments, the radionuclide 55Co2+ has been shown to accumulate in degenerating cerebral tissue similar to Ca2+. The potential role of 55Co2+ for in vivo brain PET imaging was investigated in four patients after ischemic stroke. PET showed uptake of 55Co2+ in damaged brain tissue irrespective of blood-brain barrier integrity, as affirmed by CT and MRI. Our preliminary results indicate that 55CoCl2 may prove to be a useful and relatively inexpensive PET radiopharmaceutical for visualization of degenerative processes in brain tissue.
Medical subject headings
- Brain
- Brain Ischemia
- Cobalt Radioisotopes
- Tomography, Emission-Computed