Regional variation and age-related changes of lysosomal enzymes in the human retinal pigment epithelium.
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- Record sourced from PubMed, PMID 8123620.
- Also identified by PMC identifier 504714.
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Abstract
In this study the activities of two lysosomal enzymes in retinal pigment epithelial (RPE) cells isolated from three regions of the human fundus were examined: the macula, the nasal midzone, and the periphery. The results obtained showed that the activities of acid phosphatase and cathepsin D were significantly higher in the RPE cells derived from the macular region when compared with those in the periphery. The values for the midzone appeared to be intermediate between the other two regions. Furthermore, the overall activity of both enzymes increased as a function of age.
Medical subject headings
- Acid Phosphatase
- Aging
- Cathepsin D
- Lysosomes
- Pigment Epithelium of Eye