Long-range cis preference in DNA homology search over the length of a Drosophila chromosome.
basic_science · Level V
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Abstract
P element-induced chromosome breakage on the X chromosome of Drosophila melanogaster was repaired six times more frequently when a homologous template was located anywhere on the X chromosome rather than on an autosome. Cis-trans comparisons confirmed that recombinational repair was more frequent when the interacting sequences were physically connected. These results suggest that the search for homology between the broken ends and a matching template sequence occurs preferentially in the cis configuration. This cis advantage operates over more than 15 megabases of DNA.
Medical subject headings
- Chromosomes
- DNA
- DNA Repair
- Drosophila melanogaster
- Gene Conversion
- Sequence Homology, Nucleic Acid