Effect of nitrous oxide and volatile anaesthetics on platelet function in man.
prospective_cohort · Level II
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Abstract
Twelve otherwise healthy male volunteers scheduled for arthroscopy of the knee were studied. The influence in vivo of nitrous oxide (N2O) per se and the addition of a halogenated volatile anaesthetic (halothane or isoflurane) on ADP-induced platelet aggregation and release of beta-thromboglobulin into plasma was evaluated. All measurements were made before surgery. We found that N2O increased platelet aggregation. Adding a halogenated anaesthetic reversed the relative hyperaggregation induced by N2O. The concentrations in plasma of the platelet release product beta thromboglobulin were not influenced by the anaesthetics.
Medical subject headings
- Anesthesia, Inhalation
- Halothane
- Isoflurane
- Nitrous Oxide
- Platelet Aggregation
- beta-Thromboglobulin