Neurotensin excites basal forebrain cholinergic neurons: ionic and signal-transduction mechanisms.
basic_science · Level V
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- Record sourced from PubMed, PMID 8146199.
- Also identified by PMC identifier 43469.
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Abstract
The whole-cell patch-clamp technique was used to investigate the effect of neurotensin on cholinergic neurons cultured from the rat nucleus basalis of Meynert. Neurotensin excited the neurons by inducing an initial inward current carried, at least in part, by Na+ and by reducing inwardly rectifying K+ conductance. Reduction of the inwardly rectifying K+ conductance was mediated by a pertussis toxin-insensitive G protein.
Medical subject headings
- Cholinergic Fibers
- Neurotensin
- Signal Transduction
- Substantia Innominata